Drug interactions
Hepatitis b vaccine + Leflunomide
Severity: Moderate
Hepatitis b vaccine and Leflunomide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Leflunomide may lower seroconversion after hepatitis B vaccination, leaving inadequate protection. The vaccine is inactivated and not infectious.
What this interaction means in plain words
Hepatitis b vaccine and Leflunomide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Antiproliferative immunosuppression may dampen humoral vaccine response.
What to do
Check anti-HBs after the series and revaccinate or use a higher-dose schedule if the response is inadequate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Leflunomide
- Bcg vaccine live + Leflunomide Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Leflunomide Contraindicated
- Leflunomide + Measles mumps and rubella vaccine live Contraindicated
- Leflunomide + Measles mumps rubella and varicella vaccine live Contraindicated
- Leflunomide + Measles vaccine Contraindicated
- Leflunomide + Smallpox vaccine live Contraindicated
Frequently asked questions
Can I take Hepatitis b vaccine with Leflunomide?
MediHelp rates the interaction as moderate. Hepatitis b vaccine and Leflunomide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Leflunomide may lower seroconversion after hepatitis B vaccination, leaving inadequate protection. The vaccine is inactivated and not infectious.
How serious is the interaction between Hepatitis b vaccine and Leflunomide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check anti-HBs after the series and revaccinate or use a higher-dose schedule if the response is inadequate.
What other medicines interact with Leflunomide?
MediHelp also lists interactions of Leflunomide with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine live. The full list is on the Leflunomide page.
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