Drug interactions
Histrelin + Hydroxyzine
Severity: Moderate
Histrelin and Hydroxyzine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Histrelin, a GnRH agonist, may prolong the QT interval through androgen deprivation, and hydroxyzine also prolongs QT. Combined use may add to arrhythmia risk, particularly in patients with cardiac disease or electrolyte abnormalities.
What this interaction means in plain words
Histrelin and Hydroxyzine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Histrelin belongs to Musculoskeletal; Hydroxyzine belongs to Respiratory.
Why it happens
Additive QT prolongation; androgen deprivation effect on repolarization plus hydroxyzine ion channel blockade.
What to do
Obtain a baseline ECG and correct electrolyte abnormalities. Monitor ECG in patients with additional QT risk factors or consider an alternative to hydroxyzine.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydroxyzine
- Droperidol + Hydroxyzine Contraindicated
- Hydroxyzine + Pimozide Contraindicated
- Hydroxyzine + Thioridazine Contraindicated
- Hydroxyzine + Vandetanib Contraindicated
- Alfentanil + Hydroxyzine Major
- Amiodarone + Hydroxyzine Major
Other interactions of Histrelin
- Amiodarone + Histrelin Major
- Anagrelide + Histrelin Major
- Histrelin + Thioridazine Major
- Alfuzosin + Histrelin Moderate
- Amisulpride + Histrelin Moderate
- Asenapine + Histrelin Moderate
Frequently asked questions
Can I take Histrelin with Hydroxyzine?
MediHelp rates the interaction as moderate. Histrelin and Hydroxyzine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Histrelin, a GnRH agonist, may prolong the QT interval through androgen deprivation, and hydroxyzine also prolongs QT. Combined use may add to arrhythmia risk, particularly in patients with cardiac disease or electrolyte abnormalities.
How serious is the interaction between Histrelin and Hydroxyzine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and correct electrolyte abnormalities. Monitor ECG in patients with additional QT risk factors or consider an alternative to hydroxyzine.
What other medicines interact with Hydroxyzine?
MediHelp also lists interactions of Hydroxyzine with, for example, Droperidol, Pimozide, Thioridazine. The full list is on the Hydroxyzine page.
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