Drug interactions
Histrelin + Indacaterol-glycopyrronium
Severity: Moderate
Histrelin and Indacaterol-glycopyrronium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Histrelin, a GnRH agonist, may prolong the QT interval through androgen deprivation. Indacaterol can add proarrhythmic effects, so the combination may raise torsades risk in susceptible patients.
What this interaction means in plain words
Histrelin and Indacaterol-glycopyrronium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Histrelin belongs to Musculoskeletal; Indacaterol-glycopyrronium belongs to Respiratory.
Why it happens
Additive effects on cardiac repolarisation, with beta-agonist related hypokalaemia.
What to do
Consider baseline and periodic ECGs in patients with cardiac risk factors and correct potassium and magnesium abnormalities.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indacaterol-glycopyrronium
Other interactions of Histrelin
- Amiodarone + Histrelin Major
- Anagrelide + Histrelin Major
- Histrelin + Thioridazine Major
- Alfuzosin + Histrelin Moderate
- Amisulpride + Histrelin Moderate
- Asenapine + Histrelin Moderate
Frequently asked questions
Can I take Histrelin with Indacaterol-glycopyrronium?
MediHelp rates the interaction as moderate. Histrelin and Indacaterol-glycopyrronium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Histrelin, a GnRH agonist, may prolong the QT interval through androgen deprivation. Indacaterol can add proarrhythmic effects, so the combination may raise torsades risk in susceptible patients.
How serious is the interaction between Histrelin and Indacaterol-glycopyrronium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider baseline and periodic ECGs in patients with cardiac risk factors and correct potassium and magnesium abnormalities.
What other medicines interact with Indacaterol-glycopyrronium?
MediHelp also lists interactions of Indacaterol-glycopyrronium with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Indacaterol-glycopyrronium page.
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