Drug interactions
Histrelin + Moxifloxacin
Severity: Moderate
Histrelin and Moxifloxacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Histrelin, a GnRH agonist, lowers testosterone and may prolong the QT interval, while moxifloxacin also prolongs QT. The combination may increase the risk of torsades de pointes.
What this interaction means in plain words
Histrelin and Moxifloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Histrelin belongs to Musculoskeletal; Moxifloxacin belongs to Anti Bacterial.
Why it happens
Additive QT prolongation, with androgen deprivation from GnRH agonists contributing to repolarisation changes.
What to do
Consider baseline and follow-up ECG and correct electrolytes. Prefer an antibiotic without QT effects in patients with additional risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Moxifloxacin
- Amiodarone + Moxifloxacin Contraindicated
- Arsenic trioxide + Moxifloxacin Contraindicated
- Disopyramide + Moxifloxacin Contraindicated
- Dofetilide + Moxifloxacin Contraindicated
- Dronedarone + Moxifloxacin Contraindicated
- Droperidol + Moxifloxacin Contraindicated
Other interactions of Histrelin
- Amiodarone + Histrelin Major
- Anagrelide + Histrelin Major
- Histrelin + Thioridazine Major
- Alfuzosin + Histrelin Moderate
- Amisulpride + Histrelin Moderate
- Asenapine + Histrelin Moderate
Frequently asked questions
Can I take Histrelin with Moxifloxacin?
MediHelp rates the interaction as moderate. Histrelin and Moxifloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Histrelin, a GnRH agonist, lowers testosterone and may prolong the QT interval, while moxifloxacin also prolongs QT. The combination may increase the risk of torsades de pointes.
How serious is the interaction between Histrelin and Moxifloxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider baseline and follow-up ECG and correct electrolytes. Prefer an antibiotic without QT effects in patients with additional risk factors.
What other medicines interact with Moxifloxacin?
MediHelp also lists interactions of Moxifloxacin with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Moxifloxacin page.
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