Drug interactions
Histrelin + Paliperidone
Severity: Moderate
Histrelin and Paliperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Histrelin, a GnRH agonist, can prolong the QT interval through androgen deprivation, and paliperidone also prolongs QTc. Together they may raise the risk of torsades de pointes.
What this interaction means in plain words
Histrelin and Paliperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Histrelin belongs to Musculoskeletal; Paliperidone belongs to Central Nervous System.
Why it happens
Additive QT prolongation, with androgen deprivation therapy contributing to repolarization changes.
What to do
Review the need for both drugs and obtain a baseline ECG with periodic follow-up. Correct potassium and magnesium abnormalities and consider alternatives in patients with additional QT risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Paliperidone
- Ibutilide + Paliperidone Contraindicated
- Paliperidone + Pimozide Contraindicated
- Paliperidone + Vandetanib Contraindicated
- Adagrasib + Paliperidone Major
- Amiodarone + Paliperidone Major
- Amisulpride + Paliperidone Major
Other interactions of Histrelin
- Amiodarone + Histrelin Major
- Anagrelide + Histrelin Major
- Histrelin + Thioridazine Major
- Alfuzosin + Histrelin Moderate
- Amisulpride + Histrelin Moderate
- Asenapine + Histrelin Moderate
Frequently asked questions
Can I take Histrelin with Paliperidone?
MediHelp rates the interaction as moderate. Histrelin and Paliperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Histrelin, a GnRH agonist, can prolong the QT interval through androgen deprivation, and paliperidone also prolongs QTc. Together they may raise the risk of torsades de pointes.
How serious is the interaction between Histrelin and Paliperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Review the need for both drugs and obtain a baseline ECG with periodic follow-up. Correct potassium and magnesium abnormalities and consider alternatives in patients with additional QT risk factors.
What other medicines interact with Paliperidone?
MediHelp also lists interactions of Paliperidone with, for example, Ibutilide, Pimozide, Vandetanib. The full list is on the Paliperidone page.
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