Drug interactions
Homatropine + Prochlorperazine
Severity: Moderate
Homatropine and Prochlorperazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Homatropine is an antimuscarinic and prochlorperazine has anticholinergic activity, so combined use can intensify dry mouth, blurred vision, constipation, urinary retention and confusion. Older patients are at greatest risk.
What this interaction means in plain words
Homatropine and Prochlorperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Homatropine belongs to Genitourinary; Prochlorperazine belongs to Central Nervous System.
Why it happens
Additive antimuscarinic effects through pharmacodynamic synergism.
What to do
Monitor for anticholinergic adverse effects and review the need for both drugs in older patients. Reduce doses or choose an alternative if symptoms occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Prochlorperazine
- Dronedarone + Prochlorperazine Contraindicated
- Ibutilide + Prochlorperazine Contraindicated
- Nilotinib + Prochlorperazine Contraindicated
- Pimozide + Prochlorperazine Contraindicated
- Prochlorperazine + Thioridazine Contraindicated
- Amiodarone + Prochlorperazine Major
Other interactions of Homatropine
- Amantadine + Homatropine Moderate
- Amitriptyline + Homatropine Moderate
- Atropine + Homatropine Moderate
- Benztropine + Homatropine Moderate
- Bethanechol + Homatropine Moderate
- Chlorpromazine + Homatropine Moderate
Frequently asked questions
Can I take Homatropine with Prochlorperazine?
MediHelp rates the interaction as moderate. Homatropine and Prochlorperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Homatropine is an antimuscarinic and prochlorperazine has anticholinergic activity, so combined use can intensify dry mouth, blurred vision, constipation, urinary retention and confusion. Older patients are at greatest risk.
How serious is the interaction between Homatropine and Prochlorperazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic adverse effects and review the need for both drugs in older patients. Reduce doses or choose an alternative if symptoms occur.
What other medicines interact with Prochlorperazine?
MediHelp also lists interactions of Prochlorperazine with, for example, Dronedarone, Ibutilide, Nilotinib. The full list is on the Prochlorperazine page.
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