Drug interactions
Human papillomavirus vaccine + Muromonab cd3
Severity: Moderate
Human papillomavirus vaccine and Muromonab cd3: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Muromonab-CD3 is a potent anti-T-cell antibody that causes marked immunosuppression, and vaccine responses are likely to be diminished. HPV vaccination during or soon after treatment may give inadequate protection.
What this interaction means in plain words
Human papillomavirus vaccine and Muromonab cd3 can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Anti-CD3-mediated T-cell depletion and inactivation impair vaccine immune responses.
What to do
Vaccinate before starting therapy where feasible. Otherwise delay vaccination until immune recovery and consider revaccination.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Human papillomavirus vaccine
- Antithymocyte globulin equine + Human papillomavirus vaccine Moderate
- Antithymocyte globulin rabbit + Human papillomavirus vaccine Moderate
- Atidarsagene autotemcel + Human papillomavirus vaccine Moderate
- Belimumab + Human papillomavirus vaccine Moderate
- Cortisone + Human papillomavirus vaccine Moderate
- Cyclosporine + Human papillomavirus vaccine Moderate
Frequently asked questions
Can I take Human papillomavirus vaccine with Muromonab cd3?
MediHelp rates the interaction as moderate. Human papillomavirus vaccine and Muromonab cd3 can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Muromonab-CD3 is a potent anti-T-cell antibody that causes marked immunosuppression, and vaccine responses are likely to be diminished. HPV vaccination during or soon after treatment may give inadequate protection.
How serious is the interaction between Human papillomavirus vaccine and Muromonab cd3?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccinate before starting therapy where feasible. Otherwise delay vaccination until immune recovery and consider revaccination.
What other medicines interact with Human papillomavirus vaccine?
MediHelp also lists interactions of Human papillomavirus vaccine with, for example, Antithymocyte globulin equine, Antithymocyte globulin rabbit, Atidarsagene autotemcel. The full list is on the Human papillomavirus vaccine page.
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