Drug interactions
Human papillomavirus vaccine + Mycophenolate
Severity: Moderate
Human papillomavirus vaccine and Mycophenolate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mycophenolate inhibits lymphocyte proliferation and can lower antibody responses to inactivated vaccines. HPV vaccine protection may be reduced in transplant and autoimmune patients taking it.
What this interaction means in plain words
Human papillomavirus vaccine and Mycophenolate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of inosine monophosphate dehydrogenase limits B- and T-lymphocyte proliferation and vaccine response.
What to do
Vaccinate before starting mycophenolate when possible; non-live HPV vaccine can still be given during treatment. Consider checking serologic response where protection is important.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Human papillomavirus vaccine
- Antithymocyte globulin equine + Human papillomavirus vaccine Moderate
- Antithymocyte globulin rabbit + Human papillomavirus vaccine Moderate
- Atidarsagene autotemcel + Human papillomavirus vaccine Moderate
- Belimumab + Human papillomavirus vaccine Moderate
- Cortisone + Human papillomavirus vaccine Moderate
- Cyclosporine + Human papillomavirus vaccine Moderate
Frequently asked questions
Can I take Human papillomavirus vaccine with Mycophenolate?
MediHelp rates the interaction as moderate. Human papillomavirus vaccine and Mycophenolate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mycophenolate inhibits lymphocyte proliferation and can lower antibody responses to inactivated vaccines. HPV vaccine protection may be reduced in transplant and autoimmune patients taking it.
How serious is the interaction between Human papillomavirus vaccine and Mycophenolate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccinate before starting mycophenolate when possible; non-live HPV vaccine can still be given during treatment. Consider checking serologic response where protection is important.
What other medicines interact with Human papillomavirus vaccine?
MediHelp also lists interactions of Human papillomavirus vaccine with, for example, Antithymocyte globulin equine, Antithymocyte globulin rabbit, Atidarsagene autotemcel. The full list is on the Human papillomavirus vaccine page.
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