Drug interactions
Human papillomavirus vaccine + Ofatumumab sc
Severity: Moderate
Human papillomavirus vaccine and Ofatumumab sc: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ofatumumab depletes B cells, which are needed to produce antibodies after vaccination. Response to HPV vaccine may therefore be reduced during treatment.
What this interaction means in plain words
Human papillomavirus vaccine and Ofatumumab sc can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Anti-CD20 B-cell depletion reduces antibody production in response to the vaccine.
What to do
Give inactivated vaccines at least 2 weeks before starting ofatumumab where possible. If vaccinated on treatment, consider assessing response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Human papillomavirus vaccine
- Antithymocyte globulin equine + Human papillomavirus vaccine Moderate
- Antithymocyte globulin rabbit + Human papillomavirus vaccine Moderate
- Atidarsagene autotemcel + Human papillomavirus vaccine Moderate
- Belimumab + Human papillomavirus vaccine Moderate
- Cortisone + Human papillomavirus vaccine Moderate
- Cyclosporine + Human papillomavirus vaccine Moderate
Frequently asked questions
Can I take Human papillomavirus vaccine with Ofatumumab sc?
MediHelp rates the interaction as moderate. Human papillomavirus vaccine and Ofatumumab sc can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ofatumumab depletes B cells, which are needed to produce antibodies after vaccination. Response to HPV vaccine may therefore be reduced during treatment.
How serious is the interaction between Human papillomavirus vaccine and Ofatumumab sc?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give inactivated vaccines at least 2 weeks before starting ofatumumab where possible. If vaccinated on treatment, consider assessing response.
What other medicines interact with Human papillomavirus vaccine?
MediHelp also lists interactions of Human papillomavirus vaccine with, for example, Antithymocyte globulin equine, Antithymocyte globulin rabbit, Atidarsagene autotemcel. The full list is on the Human papillomavirus vaccine page.
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