Drug interactions
Human papillomavirus vaccine + Rituximab-hyaluronidase
Severity: Moderate
Human papillomavirus vaccine and Rituximab-hyaluronidase: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rituximab depletes B cells and can substantially reduce antibody responses to vaccines, including HPV vaccine. Vaccination during or shortly after treatment may fail to provide adequate protection.
What this interaction means in plain words
Human papillomavirus vaccine and Rituximab-hyaluronidase can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Pharmacodynamic antagonism: CD20-mediated B-cell depletion impairs humoral vaccine response.
What to do
Give HPV vaccination at least 4 weeks before starting rituximab where feasible. If vaccinated during therapy, consider revaccination once B-cell recovery has occurred.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Human papillomavirus vaccine
- Antithymocyte globulin equine + Human papillomavirus vaccine Moderate
- Antithymocyte globulin rabbit + Human papillomavirus vaccine Moderate
- Atidarsagene autotemcel + Human papillomavirus vaccine Moderate
- Belimumab + Human papillomavirus vaccine Moderate
- Cortisone + Human papillomavirus vaccine Moderate
- Cyclosporine + Human papillomavirus vaccine Moderate
Frequently asked questions
Can I take Human papillomavirus vaccine with Rituximab-hyaluronidase?
MediHelp rates the interaction as moderate. Human papillomavirus vaccine and Rituximab-hyaluronidase can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rituximab depletes B cells and can substantially reduce antibody responses to vaccines, including HPV vaccine. Vaccination during or shortly after treatment may fail to provide adequate protection.
How serious is the interaction between Human papillomavirus vaccine and Rituximab-hyaluronidase?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give HPV vaccination at least 4 weeks before starting rituximab where feasible. If vaccinated during therapy, consider revaccination once B-cell recovery has occurred.
What other medicines interact with Human papillomavirus vaccine?
MediHelp also lists interactions of Human papillomavirus vaccine with, for example, Antithymocyte globulin equine, Antithymocyte globulin rabbit, Atidarsagene autotemcel. The full list is on the Human papillomavirus vaccine page.
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