Drug interactions
Human papillomavirus vaccine nonavalent + Leflunomide
Severity: Moderate
Human papillomavirus vaccine nonavalent and Leflunomide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Immunosuppression from leflunomide may blunt the antibody response to the HPV vaccine. Because it is a non-live vaccine, it is safe to give but protection may be less robust.
What this interaction means in plain words
Human papillomavirus vaccine nonavalent and Leflunomide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Leflunomide inhibits lymphocyte proliferation, reducing vaccine-induced immune response.
What to do
Give the vaccine series as indicated and do not withhold it; ideally vaccinate before starting leflunomide when feasible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Human papillomavirus vaccine nonavalent and Leflunomide, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Leflunomide
- Bcg vaccine live + Leflunomide Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Leflunomide Contraindicated
- Leflunomide + Measles mumps and rubella vaccine live Contraindicated
- Leflunomide + Measles mumps rubella and varicella vaccine live Contraindicated
- Leflunomide + Measles vaccine Contraindicated
- Leflunomide + Smallpox vaccine live Contraindicated
Frequently asked questions
Can I take Human papillomavirus vaccine nonavalent with Leflunomide?
MediHelp rates the interaction as moderate. Human papillomavirus vaccine nonavalent and Leflunomide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Immunosuppression from leflunomide may blunt the antibody response to the HPV vaccine. Because it is a non-live vaccine, it is safe to give but protection may be less robust.
How serious is the interaction between Human papillomavirus vaccine nonavalent and Leflunomide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give the vaccine series as indicated and do not withhold it; ideally vaccinate before starting leflunomide when feasible.
What other medicines interact with Leflunomide?
MediHelp also lists interactions of Leflunomide with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine live. The full list is on the Leflunomide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
