Drug interactions
Foscarnet + Zoledronic acid
Severity: Moderate
Foscarnet and Zoledronic acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs lower serum calcium: zoledronic acid by inhibiting bone resorption and foscarnet by chelating ionized calcium. Together they may cause symptomatic hypocalcemia, including tetany, paresthesias and seizures or arrhythmias.
What this interaction means in plain words
Foscarnet and Zoledronic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Foscarnet belongs to Anti Virals; Zoledronic acid belongs to Musculoskeletal.
Why it happens
Additive lowering of serum calcium through bone resorption inhibition and chelation of ionized calcium.
What to do
Check calcium, magnesium and ionized calcium before and during therapy, and correct deficits. Replace calcium and vitamin D as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Zoledronic acid
- Amikacin + Zoledronic acid Moderate
- Bumetanide + Zoledronic acid Moderate
- Dichlorphenamide + Zoledronic acid Moderate
- Ethacrynic acid + Zoledronic acid Moderate
- Gentamicin + Zoledronic acid Moderate
- Human parathyroid hormone recombinant + Zoledronic acid Moderate
Other interactions of Foscarnet
- Cidofovir + Foscarnet Contraindicated
- Foscarnet + Pimozide Contraindicated
- Foscarnet + Thioridazine Contraindicated
- Foscarnet + Vandetanib Contraindicated
- Adagrasib + Foscarnet Major
- Adefovir + Foscarnet Major
Frequently asked questions
Can I take Foscarnet with Zoledronic acid?
MediHelp rates the interaction as moderate. Foscarnet and Zoledronic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs lower serum calcium: zoledronic acid by inhibiting bone resorption and foscarnet by chelating ionized calcium. Together they may cause symptomatic hypocalcemia, including tetany, paresthesias and seizures or arrhythmias.
How serious is the interaction between Foscarnet and Zoledronic acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check calcium, magnesium and ionized calcium before and during therapy, and correct deficits. Replace calcium and vitamin D as needed.
What other medicines interact with Zoledronic acid?
MediHelp also lists interactions of Zoledronic acid with, for example, Amikacin, Bumetanide, Dichlorphenamide. The full list is on the Zoledronic acid page.
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