Drug interactions
Ethacrynic acid + Zoledronic acid
Severity: Moderate
Ethacrynic acid and Zoledronic acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Zoledronic acid lowers serum calcium and loop diuretics such as ethacrynic acid increase urinary calcium loss. Together they may add to the risk of hypocalcemia, and ethacrynic acid can also add to electrolyte disturbances such as hypomagnesemia.
What this interaction means in plain words
Ethacrynic acid and Zoledronic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ethacrynic acid belongs to Cardiovascular; Zoledronic acid belongs to Musculoskeletal.
Why it happens
Additive calcium lowering through inhibition of bone resorption (bisphosphonate) and increased renal calcium excretion (loop diuretic).
What to do
Correct hypocalcemia and vitamin D deficiency before zoledronic acid. Monitor serum calcium and magnesium after dosing and supplement calcium as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Zoledronic acid
- Amikacin + Zoledronic acid Moderate
- Bumetanide + Zoledronic acid Moderate
- Dichlorphenamide + Zoledronic acid Moderate
- Foscarnet + Zoledronic acid Moderate
- Gentamicin + Zoledronic acid Moderate
- Human parathyroid hormone recombinant + Zoledronic acid Moderate
Other interactions of Ethacrynic acid
Frequently asked questions
Can I take Ethacrynic acid with Zoledronic acid?
MediHelp rates the interaction as moderate. Ethacrynic acid and Zoledronic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Zoledronic acid lowers serum calcium and loop diuretics such as ethacrynic acid increase urinary calcium loss. Together they may add to the risk of hypocalcemia, and ethacrynic acid can also add to electrolyte disturbances such as hypomagnesemia.
How serious is the interaction between Ethacrynic acid and Zoledronic acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Correct hypocalcemia and vitamin D deficiency before zoledronic acid. Monitor serum calcium and magnesium after dosing and supplement calcium as needed.
What other medicines interact with Zoledronic acid?
MediHelp also lists interactions of Zoledronic acid with, for example, Amikacin, Bumetanide, Dichlorphenamide. The full list is on the Zoledronic acid page.
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