Drug interactions
Hydralazine + Methamphetamine
Severity: Moderate
Hydralazine and Methamphetamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Methamphetamine raises blood pressure and heart rate and can counteract the antihypertensive effect of hydralazine. Tachycardia may be intensified.
What this interaction means in plain words
Hydralazine and Methamphetamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydralazine belongs to Cardiovascular; Methamphetamine belongs to Central Nervous System.
Why it happens
Sympathomimetic catecholamine release opposes vasodilation by hydralazine.
What to do
Monitor blood pressure and heart rate and adjust antihypertensive therapy as needed. Avoid nonprescribed use.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydralazine
- Amifostine + Hydralazine Major
- Aceclofenac + Hydralazine Moderate
- Acemetacin + Hydralazine Moderate
- Aldesleukin + Hydralazine Moderate
- Avanafil + Hydralazine Moderate
- Benzphetamine + Hydralazine Moderate
Other interactions of Methamphetamine
- Isocarboxazid + Methamphetamine Contraindicated
- Linezolid + Methamphetamine Contraindicated
- Methamphetamine + Phenelzine Contraindicated
- Methamphetamine + Procarbazine Contraindicated
- Methamphetamine + Rasagiline Contraindicated
- Methamphetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Hydralazine with Methamphetamine?
MediHelp rates the interaction as moderate. Hydralazine and Methamphetamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Methamphetamine raises blood pressure and heart rate and can counteract the antihypertensive effect of hydralazine. Tachycardia may be intensified.
How serious is the interaction between Hydralazine and Methamphetamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate and adjust antihypertensive therapy as needed. Avoid nonprescribed use.
What other medicines interact with Hydralazine?
MediHelp also lists interactions of Hydralazine with, for example, Amifostine, Aceclofenac, Acemetacin. The full list is on the Hydralazine page.
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