Drug interactions
Hydralazine + Pretomanid
Severity: Moderate
Hydralazine and Pretomanid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pretomanid regimens are associated with hepatotoxicity, and hydralazine has been linked to rare hepatic injury. Combined use may modestly increase hepatic risk.
What this interaction means in plain words
Hydralazine and Pretomanid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydralazine belongs to Cardiovascular; Pretomanid belongs to Anti Bacterial.
Why it happens
Potential additive hepatotoxicity.
What to do
Monitor liver function tests regularly during treatment. Consider an alternative antihypertensive if liver enzymes rise.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Hydralazine and Pretomanid, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Hydralazine
- Amifostine + Hydralazine Major
- Aceclofenac + Hydralazine Moderate
- Acemetacin + Hydralazine Moderate
- Aldesleukin + Hydralazine Moderate
- Avanafil + Hydralazine Moderate
- Benzphetamine + Hydralazine Moderate
Other interactions of Pretomanid
Frequently asked questions
Can I take Hydralazine with Pretomanid?
MediHelp rates the interaction as moderate. Hydralazine and Pretomanid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pretomanid regimens are associated with hepatotoxicity, and hydralazine has been linked to rare hepatic injury. Combined use may modestly increase hepatic risk.
How serious is the interaction between Hydralazine and Pretomanid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver function tests regularly during treatment. Consider an alternative antihypertensive if liver enzymes rise.
What other medicines interact with Hydralazine?
MediHelp also lists interactions of Hydralazine with, for example, Amifostine, Aceclofenac, Acemetacin. The full list is on the Hydralazine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
