Drug interactions
Hydralazine + Propylhexedrine
Severity: Minor
Hydralazine and Propylhexedrine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Propylhexedrine is a sympathomimetic nasal decongestant that is mainly used by inhalation. At normal doses systemic effects are small, but misuse or excessive dosing can raise blood pressure and heart rate. Any pressor effect would oppose hydralazine's action.
What this interaction means in plain words
Hydralazine and Propylhexedrine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Hydralazine belongs to Cardiovascular; Propylhexedrine belongs to Respiratory.
Why it happens
Sympathomimetic vasoconstriction can oppose the vasodilating effect of hydralazine, though systemic exposure from inhalation is low.
What to do
Advise patients to use the inhaler only as directed and to avoid overuse. Monitor blood pressure if frequent use is reported.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydralazine
- Amifostine + Hydralazine Major
- Aceclofenac + Hydralazine Moderate
- Acemetacin + Hydralazine Moderate
- Aldesleukin + Hydralazine Moderate
- Avanafil + Hydralazine Moderate
- Benzphetamine + Hydralazine Moderate
Other interactions of Propylhexedrine
- Isocarboxazid + Propylhexedrine Contraindicated
- Phenelzine + Propylhexedrine Contraindicated
- Linezolid + Propylhexedrine Major
- Propylhexedrine + Selegiline Major
- Propylhexedrine + Tranylcypromine Major
- Adrenaline-articaine + Propylhexedrine Moderate
Frequently asked questions
Can I take Hydralazine with Propylhexedrine?
MediHelp rates the interaction as minor. Hydralazine and Propylhexedrine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Propylhexedrine is a sympathomimetic nasal decongestant that is mainly used by inhalation. At normal doses systemic effects are small, but misuse or excessive dosing can raise blood pressure and heart rate. Any pressor effect would oppose hydralazine's action.
How serious is the interaction between Hydralazine and Propylhexedrine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to use the inhaler only as directed and to avoid overuse. Monitor blood pressure if frequent use is reported.
What other medicines interact with Hydralazine?
MediHelp also lists interactions of Hydralazine with, for example, Amifostine, Aceclofenac, Acemetacin. The full list is on the Hydralazine page.
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