Drug interactions
Hydralazine + Sotalol
Severity: Minor
Hydralazine and Sotalol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs lower blood pressure, so the effects add together. Beta-blockers are often combined with hydralazine on purpose because they blunt the reflex tachycardia of hydralazine, but hypotension can still occur.
What this interaction means in plain words
Hydralazine and Sotalol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Hydralazine belongs to Cardiovascular; Sotalol belongs to Cardiovascular.
Why it happens
Additive blood pressure lowering from arteriolar vasodilation and beta-blockade.
What to do
Monitor blood pressure and heart rate when starting or adjusting either drug, and titrate doses as needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sotalol
- Arsenic trioxide + Sotalol Contraindicated
- Artemether / lumefantrine + Sotalol Contraindicated
- Disopyramide + Sotalol Contraindicated
- Dofetilide + Sotalol Contraindicated
- Dronedarone + Sotalol Contraindicated
- Droperidol + Sotalol Contraindicated
Other interactions of Hydralazine
- Amifostine + Hydralazine Major
- Aceclofenac + Hydralazine Moderate
- Acemetacin + Hydralazine Moderate
- Aldesleukin + Hydralazine Moderate
- Avanafil + Hydralazine Moderate
- Benzphetamine + Hydralazine Moderate
Frequently asked questions
Can I take Hydralazine with Sotalol?
MediHelp rates the interaction as minor. Hydralazine and Sotalol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both drugs lower blood pressure, so the effects add together. Beta-blockers are often combined with hydralazine on purpose because they blunt the reflex tachycardia of hydralazine, but hypotension can still occur.
How serious is the interaction between Hydralazine and Sotalol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate when starting or adjusting either drug, and titrate doses as needed.
What other medicines interact with Sotalol?
MediHelp also lists interactions of Sotalol with, for example, Arsenic trioxide, Artemether / lumefantrine, Disopyramide. The full list is on the Sotalol page.
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