Drug interactions
Hydrochlorothiazide + Hydrochlorothiazide-telmisartan
Severity: Moderate
Hydrochlorothiazide and Hydrochlorothiazide-telmisartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The combination product already contains hydrochlorothiazide, so adding it separately duplicates the thiazide. This increases the risk of hypotension, volume depletion, hyponatremia, hypokalemia and renal impairment.
What this interaction means in plain words
Hydrochlorothiazide and Hydrochlorothiazide-telmisartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrochlorothiazide belongs to Cardiovascular; Hydrochlorothiazide-telmisartan belongs to Cardiovascular.
Why it happens
Duplicate thiazide therapy causes additive inhibition of the sodium-chloride cotransporter, with excess diuresis and electrolyte loss.
What to do
Avoid giving both and adjust the thiazide dose through the combination product or a single agent. If both were taken, check electrolytes and renal function.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-telmisartan
- Aliskiren + Hydrochlorothiazide-telmisartan Contraindicated
- Dofetilide + Hydrochlorothiazide-telmisartan Contraindicated
- Hydrochlorothiazide-telmisartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-telmisartan Major
- Amifostine + Hydrochlorothiazide-telmisartan Major
- Amiloride + Hydrochlorothiazide-telmisartan Major
Other interactions of Hydrochlorothiazide
Frequently asked questions
Can I take Hydrochlorothiazide with Hydrochlorothiazide-telmisartan?
MediHelp rates the interaction as moderate. Hydrochlorothiazide and Hydrochlorothiazide-telmisartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. The combination product already contains hydrochlorothiazide, so adding it separately duplicates the thiazide. This increases the risk of hypotension, volume depletion, hyponatremia, hypokalemia and renal impairment.
How serious is the interaction between Hydrochlorothiazide and Hydrochlorothiazide-telmisartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid giving both and adjust the thiazide dose through the combination product or a single agent. If both were taken, check electrolytes and renal function.
What other medicines interact with Hydrochlorothiazide-telmisartan?
MediHelp also lists interactions of Hydrochlorothiazide-telmisartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-telmisartan page.
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