Drug interactions
Hydrochlorothiazide + Hydrochlorothiazide-valsartan
Severity: Moderate
Hydrochlorothiazide and Hydrochlorothiazide-valsartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The combination product already contains hydrochlorothiazide, so adding it separately duplicates the thiazide and increases the risk of excessive diuresis, hypotension, hyponatremia, hypokalemia, and hyperglycemia or hyperuricemia.
What this interaction means in plain words
Hydrochlorothiazide and Hydrochlorothiazide-valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrochlorothiazide belongs to Cardiovascular; Hydrochlorothiazide-valsartan belongs to Cardiovascular.
Why it happens
Therapeutic duplication leading to additive thiazide effects on renal sodium and potassium handling.
What to do
Avoid giving separate hydrochlorothiazide with the combination product and adjust the regimen to a single thiazide source. If the dose is changed, monitor electrolytes and blood pressure.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-valsartan
- Aliskiren + Hydrochlorothiazide-valsartan Contraindicated
- Dofetilide + Hydrochlorothiazide-valsartan Contraindicated
- Hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-valsartan Major
- Amifostine + Hydrochlorothiazide-valsartan Major
- Amiloride + Hydrochlorothiazide-valsartan Major
Other interactions of Hydrochlorothiazide
Frequently asked questions
Can I take Hydrochlorothiazide with Hydrochlorothiazide-valsartan?
MediHelp rates the interaction as moderate. Hydrochlorothiazide and Hydrochlorothiazide-valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. The combination product already contains hydrochlorothiazide, so adding it separately duplicates the thiazide and increases the risk of excessive diuresis, hypotension, hyponatremia, hypokalemia, and hyperglycemia or hyperuricemia.
How serious is the interaction between Hydrochlorothiazide and Hydrochlorothiazide-valsartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid giving separate hydrochlorothiazide with the combination product and adjust the regimen to a single thiazide source. If the dose is changed, monitor electrolytes and blood pressure.
What other medicines interact with Hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-valsartan page.
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