Drug interactions
Hydrochlorothiazide + Ibuprofen
Severity: Moderate
Hydrochlorothiazide and Ibuprofen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ibuprofen can reduce the diuretic and antihypertensive effect of thiazides. In volume-depleted or elderly patients, the combination also raises the risk of acute kidney injury.
What this interaction means in plain words
Hydrochlorothiazide and Ibuprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrochlorothiazide belongs to Cardiovascular; Ibuprofen belongs to Musculoskeletal.
Why it happens
NSAIDs inhibit renal prostaglandins, causing sodium and water retention and reduced renal perfusion, which opposes thiazide action.
What to do
Monitor blood pressure, fluid status and renal function, particularly in older or dehydrated patients; use the lowest NSAID dose for the shortest time.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ibuprofen
- Ibuprofen + Ketorolac Contraindicated
- Ibuprofen + Ketorolac intranasal Contraindicated
- Acemetacin + Ibuprofen Major
- Alteplase + Ibuprofen Major
- Amiloride + Ibuprofen Major
- Apixaban + Ibuprofen Major
Other interactions of Hydrochlorothiazide
Frequently asked questions
Can I take Hydrochlorothiazide with Ibuprofen?
MediHelp rates the interaction as moderate. Hydrochlorothiazide and Ibuprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ibuprofen can reduce the diuretic and antihypertensive effect of thiazides. In volume-depleted or elderly patients, the combination also raises the risk of acute kidney injury.
How serious is the interaction between Hydrochlorothiazide and Ibuprofen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, fluid status and renal function, particularly in older or dehydrated patients; use the lowest NSAID dose for the shortest time.
What other medicines interact with Ibuprofen?
MediHelp also lists interactions of Ibuprofen with, for example, Ketorolac, Ketorolac intranasal, Acemetacin. The full list is on the Ibuprofen page.
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