Drug interactions
Hydrochlorothiazide + Insulin degludec-liraglutide
Severity: Moderate
Hydrochlorothiazide and Insulin degludec-liraglutide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazide diuretics can reduce insulin sensitivity and raise blood glucose, partly offsetting insulin and liraglutide. The effect is usually modest and dose-related.
What this interaction means in plain words
Hydrochlorothiazide and Insulin degludec-liraglutide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrochlorothiazide belongs to Cardiovascular; Insulin degludec-liraglutide belongs to Endocrine.
Why it happens
Thiazide-induced hypokalemia and decreased insulin sensitivity cause pharmacodynamic antagonism.
What to do
Monitor glucose and potassium when the thiazide is started or the dose increased. Adjust antidiabetic therapy if control worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin degludec-liraglutide
Other interactions of Hydrochlorothiazide
Frequently asked questions
Can I take Hydrochlorothiazide with Insulin degludec-liraglutide?
MediHelp rates the interaction as moderate. Hydrochlorothiazide and Insulin degludec-liraglutide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thiazide diuretics can reduce insulin sensitivity and raise blood glucose, partly offsetting insulin and liraglutide. The effect is usually modest and dose-related.
How serious is the interaction between Hydrochlorothiazide and Insulin degludec-liraglutide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose and potassium when the thiazide is started or the dose increased. Adjust antidiabetic therapy if control worsens.
What other medicines interact with Insulin degludec-liraglutide?
MediHelp also lists interactions of Insulin degludec-liraglutide with, for example, Albiglutide, Chlorpropamide, Clozapine. The full list is on the Insulin degludec-liraglutide page.
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