Drug interactions
Hydrochlorothiazide + Insulin glargine-lixisenatide
Severity: Minor
Hydrochlorothiazide and Insulin glargine-lixisenatide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazide diuretics can impair glucose tolerance and raise blood glucose, partly offsetting the effect of antidiabetic therapy. The effect is generally modest and is more evident at higher doses.
What this interaction means in plain words
Hydrochlorothiazide and Insulin glargine-lixisenatide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Hydrochlorothiazide belongs to Cardiovascular; Insulin glargine-lixisenatide belongs to Endocrine.
Why it happens
Thiazide-induced hypokalemia and reduced insulin secretion and sensitivity oppose glucose lowering.
What to do
Monitor blood glucose and serum potassium after starting or changing hydrochlorothiazide, and adjust the antidiabetic dose if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Insulin glargine-lixisenatide
- Albiglutide + Insulin glargine-lixisenatide Major
- Chlorpropamide + Insulin glargine-lixisenatide Major
- Dulaglutide + Insulin glargine-lixisenatide Major
- Ethanol + Insulin glargine-lixisenatide Major
- Exenatide injectable + Insulin glargine-lixisenatide Major
- Glimepiride + Insulin glargine-lixisenatide Major
Other interactions of Hydrochlorothiazide
Frequently asked questions
Can I take Hydrochlorothiazide with Insulin glargine-lixisenatide?
MediHelp rates the interaction as minor. Hydrochlorothiazide and Insulin glargine-lixisenatide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Thiazide diuretics can impair glucose tolerance and raise blood glucose, partly offsetting the effect of antidiabetic therapy. The effect is generally modest and is more evident at higher doses.
How serious is the interaction between Hydrochlorothiazide and Insulin glargine-lixisenatide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and serum potassium after starting or changing hydrochlorothiazide, and adjust the antidiabetic dose if needed.
What other medicines interact with Insulin glargine-lixisenatide?
MediHelp also lists interactions of Insulin glargine-lixisenatide with, for example, Albiglutide, Chlorpropamide, Dulaglutide. The full list is on the Insulin glargine-lixisenatide page.
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