Drug interactions
Hydrochlorothiazide + Magnesium citrate
Severity: Minor
Hydrochlorothiazide and Magnesium citrate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrochlorothiazide can increase urinary magnesium loss and lower serum magnesium with long-term use. Occasional magnesium citrate is barely affected.
What this interaction means in plain words
Hydrochlorothiazide and Magnesium citrate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Hydrochlorothiazide belongs to Cardiovascular; Magnesium citrate belongs to Gastrointestinal Tract.
Why it happens
Thiazides reduce distal renal magnesium reabsorption.
What to do
Check serum magnesium periodically in long-term thiazide therapy and supplement if low.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Magnesium citrate
- Ciprofloxacin + Magnesium citrate Major
- Baloxavir marboxil + Magnesium citrate Moderate
- Bictegravir + Magnesium citrate Moderate
- Cabotegravir + Magnesium citrate Moderate
- Cholecalciferol + Magnesium citrate Moderate
- Deferiprone + Magnesium citrate Moderate
Other interactions of Hydrochlorothiazide
Frequently asked questions
Can I take Hydrochlorothiazide with Magnesium citrate?
MediHelp rates the interaction as minor. Hydrochlorothiazide and Magnesium citrate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Hydrochlorothiazide can increase urinary magnesium loss and lower serum magnesium with long-term use. Occasional magnesium citrate is barely affected.
How serious is the interaction between Hydrochlorothiazide and Magnesium citrate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum magnesium periodically in long-term thiazide therapy and supplement if low.
What other medicines interact with Magnesium citrate?
MediHelp also lists interactions of Magnesium citrate with, for example, Ciprofloxacin, Baloxavir marboxil, Bictegravir. The full list is on the Magnesium citrate page.
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