Drug interactions
Hydrochlorothiazide + Meloxicam
Severity: Moderate
Hydrochlorothiazide and Meloxicam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can blunt the diuretic and antihypertensive effects of thiazides. In volume-depleted patients the combination also raises the risk of acute kidney injury.
What this interaction means in plain words
Hydrochlorothiazide and Meloxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrochlorothiazide belongs to Cardiovascular; Meloxicam belongs to Musculoskeletal.
Why it happens
Meloxicam inhibits renal prostaglandin synthesis, causing sodium and water retention and reducing renal perfusion.
What to do
Monitor blood pressure, renal function and electrolytes, and ensure adequate hydration. Use the lowest effective NSAID dose for the shortest duration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Meloxicam
- Ketorolac intranasal + Meloxicam Contraindicated
- Ketorolac + Meloxicam Contraindicated
- Aceclofenac + Meloxicam Major
- Acemetacin + Meloxicam Major
- Acetylsalicylic acid + Meloxicam Major
- Alteplase + Meloxicam Major
Other interactions of Hydrochlorothiazide
Frequently asked questions
Can I take Hydrochlorothiazide with Meloxicam?
MediHelp rates the interaction as moderate. Hydrochlorothiazide and Meloxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs can blunt the diuretic and antihypertensive effects of thiazides. In volume-depleted patients the combination also raises the risk of acute kidney injury.
How serious is the interaction between Hydrochlorothiazide and Meloxicam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, renal function and electrolytes, and ensure adequate hydration. Use the lowest effective NSAID dose for the shortest duration.
What other medicines interact with Meloxicam?
MediHelp also lists interactions of Meloxicam with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Meloxicam page.
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