Drug interactions
Hydrochlorothiazide + Metformin-repaglinide
Severity: Moderate
Hydrochlorothiazide and Metformin-repaglinide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrochlorothiazide can raise blood glucose and so reduce the effectiveness of metformin and repaglinide. It may also slightly increase metformin exposure, particularly when volume depletion or renal impairment is present.
What this interaction means in plain words
Hydrochlorothiazide and Metformin-repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrochlorothiazide belongs to Cardiovascular; Metformin-repaglinide belongs to Endocrine.
Why it happens
Thiazide-induced hypokalemia and insulin resistance antagonize antidiabetics, with possible competition for renal tubular secretion of metformin.
What to do
Monitor blood glucose, potassium and renal function after starting or changing hydrochlorothiazide, and adjust antidiabetic therapy if control worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin-repaglinide
Other interactions of Hydrochlorothiazide
Frequently asked questions
Can I take Hydrochlorothiazide with Metformin-repaglinide?
MediHelp rates the interaction as moderate. Hydrochlorothiazide and Metformin-repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Hydrochlorothiazide can raise blood glucose and so reduce the effectiveness of metformin and repaglinide. It may also slightly increase metformin exposure, particularly when volume depletion or renal impairment is present.
How serious is the interaction between Hydrochlorothiazide and Metformin-repaglinide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose, potassium and renal function after starting or changing hydrochlorothiazide, and adjust antidiabetic therapy if control worsens.
What other medicines interact with Metformin-repaglinide?
MediHelp also lists interactions of Metformin-repaglinide with, for example, Gemfibrozil, Apalutamide, Clarithromycin. The full list is on the Metformin-repaglinide page.
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