Drug interactions
Hydrochlorothiazide + Naproxen
Severity: Moderate
Hydrochlorothiazide and Naproxen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Naproxen can diminish the antihypertensive and diuretic effects of thiazides and, in volume-depleted patients, increase the risk of acute kidney injury.
What this interaction means in plain words
Hydrochlorothiazide and Naproxen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrochlorothiazide belongs to Cardiovascular; Naproxen belongs to Musculoskeletal.
Why it happens
NSAID inhibition of renal prostaglandins causes sodium and water retention and reduced renal perfusion, opposing thiazide effects.
What to do
Monitor blood pressure, fluid status and serum creatinine, and ensure hydration. Use the lowest effective naproxen dose for the shortest duration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Naproxen
- Ketorolac intranasal + Naproxen Contraindicated
- Ketorolac + Naproxen Contraindicated
- Aceclofenac + Naproxen Major
- Acemetacin + Naproxen Major
- Acetylsalicylic acid + Naproxen Major
- Alteplase + Naproxen Major
Other interactions of Hydrochlorothiazide
Frequently asked questions
Can I take Hydrochlorothiazide with Naproxen?
MediHelp rates the interaction as moderate. Hydrochlorothiazide and Naproxen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Naproxen can diminish the antihypertensive and diuretic effects of thiazides and, in volume-depleted patients, increase the risk of acute kidney injury.
How serious is the interaction between Hydrochlorothiazide and Naproxen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, fluid status and serum creatinine, and ensure hydration. Use the lowest effective naproxen dose for the shortest duration.
What other medicines interact with Naproxen?
MediHelp also lists interactions of Naproxen with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Naproxen page.
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