Drug interactions
Hydrochlorothiazide + Quinine
Severity: Moderate
Hydrochlorothiazide and Quinine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrochlorothiazide may modestly affect quinine clearance, but the more relevant concern is that diuretic-induced hypokalemia or hypomagnesemia can increase the risk of QT prolongation with quinine.
What this interaction means in plain words
Hydrochlorothiazide and Quinine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrochlorothiazide belongs to Cardiovascular; Quinine belongs to Anti Parasitic.
Why it happens
Possible competition for renal tubular secretion, plus diuretic-induced electrolyte loss that adds to QT risk.
What to do
Check potassium and magnesium and correct deficits before and during quinine therapy. Obtain an ECG in patients with other QT risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Hydrochlorothiazide and Quinine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Quinine
- Arsenic trioxide + Quinine Contraindicated
- Dofetilide + Quinine Contraindicated
- Dronedarone + Quinine Contraindicated
- Ibutilide + Quinine Contraindicated
- Mefloquine + Quinine Contraindicated
- Nilotinib + Quinine Contraindicated
Other interactions of Hydrochlorothiazide
Frequently asked questions
Can I take Hydrochlorothiazide with Quinine?
MediHelp rates the interaction as moderate. Hydrochlorothiazide and Quinine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Hydrochlorothiazide may modestly affect quinine clearance, but the more relevant concern is that diuretic-induced hypokalemia or hypomagnesemia can increase the risk of QT prolongation with quinine.
How serious is the interaction between Hydrochlorothiazide and Quinine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check potassium and magnesium and correct deficits before and during quinine therapy. Obtain an ECG in patients with other QT risk factors.
What other medicines interact with Quinine?
MediHelp also lists interactions of Quinine with, for example, Arsenic trioxide, Dofetilide, Dronedarone. The full list is on the Quinine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
