Drug interactions
Hydrochlorothiazide + Sacubitril-valsartan
Severity: Moderate
Hydrochlorothiazide and Sacubitril-valsartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrochlorothiazide lowers potassium and volume, partially offsetting potassium retention from sacubitril-valsartan, but the combination can cause additive hypotension and renal function changes. It is commonly used together, and the net electrolyte effect varies between patients.
What this interaction means in plain words
Hydrochlorothiazide and Sacubitril-valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrochlorothiazide belongs to Cardiovascular; Sacubitril-valsartan belongs to Cardiovascular.
Why it happens
Opposing effects on potassium handling and additive blood pressure lowering and volume depletion.
What to do
Monitor blood pressure, serum potassium, sodium and creatinine after initiation or dose changes. Reduce the diuretic dose if symptomatic hypotension or volume depletion occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sacubitril-valsartan
- Aliskiren + Sacubitril-valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Enalapril + Sacubitril-valsartan Contraindicated
- Fosinopril + Sacubitril-valsartan Contraindicated
- Lisinopril + Sacubitril-valsartan Contraindicated
Other interactions of Hydrochlorothiazide
Frequently asked questions
Can I take Hydrochlorothiazide with Sacubitril-valsartan?
MediHelp rates the interaction as moderate. Hydrochlorothiazide and Sacubitril-valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Hydrochlorothiazide lowers potassium and volume, partially offsetting potassium retention from sacubitril-valsartan, but the combination can cause additive hypotension and renal function changes. It is commonly used together, and the net electrolyte effect varies between patients.
How serious is the interaction between Hydrochlorothiazide and Sacubitril-valsartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, serum potassium, sodium and creatinine after initiation or dose changes. Reduce the diuretic dose if symptomatic hypotension or volume depletion occurs.
What other medicines interact with Sacubitril-valsartan?
MediHelp also lists interactions of Sacubitril-valsartan with, for example, Aliskiren, Benazepril, Captopril. The full list is on the Sacubitril-valsartan page.
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