Drug interactions
Hydrochlorothiazide + Tolmetin
Severity: Moderate
Hydrochlorothiazide and Tolmetin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs such as tolmetin can blunt the diuretic and antihypertensive effect of thiazide diuretics. In susceptible patients, such as the elderly or those who are volume depleted, the combination can also impair renal function.
What this interaction means in plain words
Hydrochlorothiazide and Tolmetin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrochlorothiazide belongs to Cardiovascular; Tolmetin belongs to Musculoskeletal.
Why it happens
NSAID inhibition of renal prostaglandin synthesis causes sodium and water retention and reduces renal blood flow, opposing thiazide effects.
What to do
Monitor blood pressure, fluid status and renal function when starting or stopping tolmetin. Keep the NSAID dose and duration as low as possible and ensure adequate hydration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tolmetin
- Ketorolac intranasal + Tolmetin Contraindicated
- Ketorolac + Tolmetin Contraindicated
- Aceclofenac + Tolmetin Major
- Acemetacin + Tolmetin Major
- Alteplase + Tolmetin Major
- Amlodipine-hydrochlorothiazide-valsartan + Tolmetin Major
Other interactions of Hydrochlorothiazide
Frequently asked questions
Can I take Hydrochlorothiazide with Tolmetin?
MediHelp rates the interaction as moderate. Hydrochlorothiazide and Tolmetin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs such as tolmetin can blunt the diuretic and antihypertensive effect of thiazide diuretics. In susceptible patients, such as the elderly or those who are volume depleted, the combination can also impair renal function.
How serious is the interaction between Hydrochlorothiazide and Tolmetin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, fluid status and renal function when starting or stopping tolmetin. Keep the NSAID dose and duration as low as possible and ensure adequate hydration.
What other medicines interact with Tolmetin?
MediHelp also lists interactions of Tolmetin with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Tolmetin page.
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