Drug interactions
Hydrochlorothiazide + Tretinoin
Severity: Minor
Hydrochlorothiazide and Tretinoin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrochlorothiazide is a recognized photosensitizer, and topical or oral tretinoin can increase skin sensitivity to sunlight. Together they may increase the risk of sunburn, though systemic exposure from topical tretinoin is small.
What this interaction means in plain words
Hydrochlorothiazide and Tretinoin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Hydrochlorothiazide belongs to Cardiovascular; Tretinoin belongs to Dermatology.
Why it happens
Additive photosensitivity (pharmacodynamic).
What to do
Advise sun protection with sunscreen and protective clothing and avoidance of prolonged sun exposure. Reassess if skin reactions develop.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide
Other interactions of Tretinoin
- Doxycycline + Tretinoin Major
- Minocycline + Tretinoin Major
- Omadacycline + Tretinoin Major
- Palovarotene + Tretinoin Major
- Sarecycline + Tretinoin Major
- Tetracycline + Tretinoin Major
Frequently asked questions
Can I take Hydrochlorothiazide with Tretinoin?
MediHelp rates the interaction as minor. Hydrochlorothiazide and Tretinoin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Hydrochlorothiazide is a recognized photosensitizer, and topical or oral tretinoin can increase skin sensitivity to sunlight. Together they may increase the risk of sunburn, though systemic exposure from topical tretinoin is small.
How serious is the interaction between Hydrochlorothiazide and Tretinoin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise sun protection with sunscreen and protective clothing and avoidance of prolonged sun exposure. Reassess if skin reactions develop.
What other medicines interact with Hydrochlorothiazide?
MediHelp also lists interactions of Hydrochlorothiazide with, for example, Dofetilide, Amifostine, Amiodarone. The full list is on the Hydrochlorothiazide page.
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