Drug interactions
Hydrochlorothiazide + Triamterene
Severity: Moderate
Hydrochlorothiazide and Triamterene: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
This fixed-dose combination is used to limit potassium loss. Hyperkalemia can still develop, particularly in renal impairment, diabetes or with ACE inhibitors, and triamterene with thiazides has been linked to renal injury.
What this interaction means in plain words
Hydrochlorothiazide and Triamterene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrochlorothiazide belongs to Cardiovascular; Triamterene belongs to Cardiovascular.
Why it happens
Triamterene blocks epithelial sodium channels, reducing potassium excretion, which counters thiazide-induced kaliuresis.
What to do
Monitor serum potassium and renal function regularly. Avoid potassium supplements and other potassium-raising drugs unless hypokalemia is documented.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide
Other interactions of Triamterene
- Amiloride + Triamterene Contraindicated
- Eplerenone + Triamterene Contraindicated
- Potassium citrate / citric acid + Triamterene Contraindicated
- Potassium citrate + Triamterene Contraindicated
- Spironolactone + Triamterene Contraindicated
- Aceclofenac + Triamterene Major
Frequently asked questions
Can I take Hydrochlorothiazide with Triamterene?
MediHelp rates the interaction as moderate. Hydrochlorothiazide and Triamterene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. This fixed-dose combination is used to limit potassium loss. Hyperkalemia can still develop, particularly in renal impairment, diabetes or with ACE inhibitors, and triamterene with thiazides has been linked to renal injury.
How serious is the interaction between Hydrochlorothiazide and Triamterene?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and renal function regularly. Avoid potassium supplements and other potassium-raising drugs unless hypokalemia is documented.
What other medicines interact with Hydrochlorothiazide?
MediHelp also lists interactions of Hydrochlorothiazide with, for example, Dofetilide, Amifostine, Amiodarone. The full list is on the Hydrochlorothiazide page.
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