Drug interactions
Hydrochlorothiazide + Valganciclovir
Severity: Minor
Hydrochlorothiazide and Valganciclovir: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrochlorothiazide may compete with ganciclovir for tubular secretion, and volume depletion from the diuretic may reduce renal clearance. Any increase in ganciclovir exposure is probably small.
What this interaction means in plain words
Hydrochlorothiazide and Valganciclovir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Hydrochlorothiazide belongs to Cardiovascular; Valganciclovir belongs to Anti Virals.
Why it happens
Possible competition for renal tubular secretion and diuretic-related reduction in renal perfusion.
What to do
Monitor creatinine clearance and blood counts, and reduce the valganciclovir dose if renal function declines.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Hydrochlorothiazide and Valganciclovir, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Valganciclovir
Other interactions of Hydrochlorothiazide
Frequently asked questions
Can I take Hydrochlorothiazide with Valganciclovir?
MediHelp rates the interaction as minor. Hydrochlorothiazide and Valganciclovir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Hydrochlorothiazide may compete with ganciclovir for tubular secretion, and volume depletion from the diuretic may reduce renal clearance. Any increase in ganciclovir exposure is probably small.
How serious is the interaction between Hydrochlorothiazide and Valganciclovir?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor creatinine clearance and blood counts, and reduce the valganciclovir dose if renal function declines.
What other medicines interact with Valganciclovir?
MediHelp also lists interactions of Valganciclovir with, for example, Didanosine, Ganciclovir, Liposomal doxorubicin. The full list is on the Valganciclovir page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
