Drug interactions
Hydrochlorothiazide-irbesartan + Ibuprofen
Severity: Moderate
Hydrochlorothiazide-irbesartan and Ibuprofen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs such as ibuprofen blunt the blood-pressure-lowering effect of thiazides and ARBs by promoting sodium and water retention. In volume-depleted or elderly patients, the triple effect on renal hemodynamics can cause acute kidney injury and hyperkalemia.
What this interaction means in plain words
Hydrochlorothiazide-irbesartan and Ibuprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrochlorothiazide-irbesartan belongs to Cardiovascular; Ibuprofen belongs to Musculoskeletal.
Why it happens
Inhibition of vasodilatory renal prostaglandins reduces glomerular perfusion and natriuresis while ARB and diuretic compromise compensatory renal autoregulation.
What to do
Avoid regular NSAID use where possible and prefer paracetamol. If needed, use the lowest dose for the shortest time and monitor blood pressure, creatinine and potassium.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-irbesartan
- Aliskiren + Hydrochlorothiazide-irbesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-irbesartan Contraindicated
- Hydrochlorothiazide-irbesartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-irbesartan Major
- Amifostine + Hydrochlorothiazide-irbesartan Major
- Amiloride + Hydrochlorothiazide-irbesartan Major
Other interactions of Ibuprofen
- Ibuprofen + Ketorolac Contraindicated
- Ibuprofen + Ketorolac intranasal Contraindicated
- Acemetacin + Ibuprofen Major
- Alteplase + Ibuprofen Major
- Amiloride + Ibuprofen Major
- Apixaban + Ibuprofen Major
Frequently asked questions
Can I take Hydrochlorothiazide-irbesartan with Ibuprofen?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-irbesartan and Ibuprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs such as ibuprofen blunt the blood-pressure-lowering effect of thiazides and ARBs by promoting sodium and water retention. In volume-depleted or elderly patients, the triple effect on renal hemodynamics can cause acute kidney injury and hyperkalemia.
How serious is the interaction between Hydrochlorothiazide-irbesartan and Ibuprofen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid regular NSAID use where possible and prefer paracetamol. If needed, use the lowest dose for the shortest time and monitor blood pressure, creatinine and potassium.
What other medicines interact with Hydrochlorothiazide-irbesartan?
MediHelp also lists interactions of Hydrochlorothiazide-irbesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-irbesartan page.
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