Drug interactions
Hydrochlorothiazide-irbesartan + Insulin degludec
Severity: Moderate
Hydrochlorothiazide-irbesartan and Insulin degludec: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The hydrochlorothiazide component can raise blood glucose and reduce the effectiveness of insulin, while irbesartan may slightly enhance insulin sensitivity. Glycemic control may therefore change, requiring insulin dose review.
What this interaction means in plain words
Hydrochlorothiazide-irbesartan and Insulin degludec can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrochlorothiazide-irbesartan belongs to Cardiovascular; Insulin degludec belongs to Endocrine.
Why it happens
Thiazides impair glucose tolerance via hypokalemia-related reduced insulin secretion and increased insulin resistance, partly opposed by ARB effects.
What to do
Monitor blood glucose and HbA1c when starting or adjusting therapy, and titrate insulin degludec as required. Maintain normal potassium.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-irbesartan
- Aliskiren + Hydrochlorothiazide-irbesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-irbesartan Contraindicated
- Hydrochlorothiazide-irbesartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-irbesartan Major
- Amifostine + Hydrochlorothiazide-irbesartan Major
- Amiloride + Hydrochlorothiazide-irbesartan Major
Other interactions of Insulin degludec
Frequently asked questions
Can I take Hydrochlorothiazide-irbesartan with Insulin degludec?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-irbesartan and Insulin degludec can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. The hydrochlorothiazide component can raise blood glucose and reduce the effectiveness of insulin, while irbesartan may slightly enhance insulin sensitivity. Glycemic control may therefore change, requiring insulin dose review.
How serious is the interaction between Hydrochlorothiazide-irbesartan and Insulin degludec?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c when starting or adjusting therapy, and titrate insulin degludec as required. Maintain normal potassium.
What other medicines interact with Hydrochlorothiazide-irbesartan?
MediHelp also lists interactions of Hydrochlorothiazide-irbesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-irbesartan page.
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