Drug interactions
Hydrochlorothiazide-irbesartan + Lofexidine
Severity: Moderate
Hydrochlorothiazide-irbesartan and Lofexidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lofexidine lowers heart rate and blood pressure through central alpha-2 agonism, and antihypertensives such as irbesartan and hydrochlorothiazide add to this effect. Patients may develop hypotension, dizziness, syncope or bradycardia.
What this interaction means in plain words
Hydrochlorothiazide-irbesartan and Lofexidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrochlorothiazide-irbesartan belongs to Cardiovascular; Lofexidine belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic blood pressure lowering from central sympatholytic action plus diuresis and angiotensin receptor blockade.
What to do
Monitor blood pressure and pulse during lofexidine therapy and hold or reduce antihypertensive doses if hypotension or bradycardia develops. Counsel the patient to rise slowly and report dizziness.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-irbesartan
- Aliskiren + Hydrochlorothiazide-irbesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-irbesartan Contraindicated
- Hydrochlorothiazide-irbesartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-irbesartan Major
- Amifostine + Hydrochlorothiazide-irbesartan Major
- Amiloride + Hydrochlorothiazide-irbesartan Major
Other interactions of Lofexidine
- Adagrasib + Lofexidine Major
- Alfuzosin + Lofexidine Major
- Amiodarone + Lofexidine Major
- Amisulpride + Lofexidine Major
- Anagrelide + Lofexidine Major
- Apomorphine + Lofexidine Major
Frequently asked questions
Can I take Hydrochlorothiazide-irbesartan with Lofexidine?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-irbesartan and Lofexidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lofexidine lowers heart rate and blood pressure through central alpha-2 agonism, and antihypertensives such as irbesartan and hydrochlorothiazide add to this effect. Patients may develop hypotension, dizziness, syncope or bradycardia.
How serious is the interaction between Hydrochlorothiazide-irbesartan and Lofexidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and pulse during lofexidine therapy and hold or reduce antihypertensive doses if hypotension or bradycardia develops. Counsel the patient to rise slowly and report dizziness.
What other medicines interact with Hydrochlorothiazide-irbesartan?
MediHelp also lists interactions of Hydrochlorothiazide-irbesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-irbesartan page.
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