Drug interactions
Hydrochlorothiazide-irbesartan + Ofloxacin
Severity: Minor
Hydrochlorothiazide-irbesartan and Ofloxacin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrochlorothiazide might slightly reduce ofloxacin clearance, but no clinically meaningful effect has been established. Both drugs can however affect QT or electrolytes in at-risk patients.
What this interaction means in plain words
Hydrochlorothiazide-irbesartan and Ofloxacin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Hydrochlorothiazide-irbesartan belongs to Cardiovascular; Ofloxacin belongs to Anti Bacterial.
Why it happens
Theoretical competition for renal tubular secretion.
What to do
No dose adjustment is generally needed. Check potassium and magnesium in patients with QT risk factors.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-irbesartan
- Aliskiren + Hydrochlorothiazide-irbesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-irbesartan Contraindicated
- Hydrochlorothiazide-irbesartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-irbesartan Major
- Amifostine + Hydrochlorothiazide-irbesartan Major
- Amiloride + Hydrochlorothiazide-irbesartan Major
Other interactions of Ofloxacin
- Ofloxacin + Thioridazine Contraindicated
- Adagrasib + Ofloxacin Major
- Amiodarone + Ofloxacin Major
- Amisulpride + Ofloxacin Major
- Anagrelide + Ofloxacin Major
- Arsenic trioxide + Ofloxacin Major
Frequently asked questions
Can I take Hydrochlorothiazide-irbesartan with Ofloxacin?
MediHelp rates the interaction as minor. Hydrochlorothiazide-irbesartan and Ofloxacin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Hydrochlorothiazide might slightly reduce ofloxacin clearance, but no clinically meaningful effect has been established. Both drugs can however affect QT or electrolytes in at-risk patients.
How serious is the interaction between Hydrochlorothiazide-irbesartan and Ofloxacin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is generally needed. Check potassium and magnesium in patients with QT risk factors.
What other medicines interact with Hydrochlorothiazide-irbesartan?
MediHelp also lists interactions of Hydrochlorothiazide-irbesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-irbesartan page.
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