Drug interactions
Hydrochlorothiazide-irbesartan + Patiromer
Severity: Minor
Hydrochlorothiazide-irbesartan and Patiromer: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Patiromer binds cations in the gut and can reduce absorption of some oral drugs, but studies with irbesartan-type agents have not shown a clinically relevant effect. Patiromer also lowers potassium, which may add to thiazide-related hypokalemia and hypomagnesemia.
What this interaction means in plain words
Hydrochlorothiazide-irbesartan and Patiromer have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Hydrochlorothiazide-irbesartan belongs to Cardiovascular; Patiromer belongs to Miscellaneous.
Why it happens
Gastrointal cation binding by patiromer; additive potassium and magnesium lowering with thiazide.
What to do
Monitor serum potassium and magnesium. Separating other oral drugs by 3 hours is the general labeling recommendation for patiromer.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-irbesartan
- Aliskiren + Hydrochlorothiazide-irbesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-irbesartan Contraindicated
- Hydrochlorothiazide-irbesartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-irbesartan Major
- Amifostine + Hydrochlorothiazide-irbesartan Major
- Amiloride + Hydrochlorothiazide-irbesartan Major
Other interactions of Patiromer
- Alogliptin-metformin + Patiromer Moderate
- Canagliflozin-metformin + Patiromer Moderate
- Carvedilol + Patiromer Moderate
- Ciprofloxacin + Patiromer Moderate
- Dapagliflozin-metformin + Patiromer Moderate
- Empagliflozin-metformin + Patiromer Moderate
Frequently asked questions
Can I take Hydrochlorothiazide-irbesartan with Patiromer?
MediHelp rates the interaction as minor. Hydrochlorothiazide-irbesartan and Patiromer have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Patiromer binds cations in the gut and can reduce absorption of some oral drugs, but studies with irbesartan-type agents have not shown a clinically relevant effect. Patiromer also lowers potassium, which may add to thiazide-related hypokalemia and hypomagnesemia.
How serious is the interaction between Hydrochlorothiazide-irbesartan and Patiromer?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and magnesium. Separating other oral drugs by 3 hours is the general labeling recommendation for patiromer.
What other medicines interact with Hydrochlorothiazide-irbesartan?
MediHelp also lists interactions of Hydrochlorothiazide-irbesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-irbesartan page.
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