Drug interactions
Hydrochlorothiazide-irbesartan + Pioglitazone
Severity: Minor
Hydrochlorothiazide-irbesartan and Pioglitazone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazides can raise blood glucose and may reduce the effect of pioglitazone. Glycemic control may worsen.
What this interaction means in plain words
Hydrochlorothiazide-irbesartan and Pioglitazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Hydrochlorothiazide-irbesartan belongs to Cardiovascular; Pioglitazone belongs to Endocrine.
Why it happens
Thiazide-induced impaired glucose tolerance opposes the antihyperglycemic effect.
What to do
Monitor blood glucose and HbA1c and adjust therapy as needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-irbesartan
- Aliskiren + Hydrochlorothiazide-irbesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-irbesartan Contraindicated
- Hydrochlorothiazide-irbesartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-irbesartan Major
- Amifostine + Hydrochlorothiazide-irbesartan Major
- Amiloride + Hydrochlorothiazide-irbesartan Major
Other interactions of Pioglitazone
Frequently asked questions
Can I take Hydrochlorothiazide-irbesartan with Pioglitazone?
MediHelp rates the interaction as minor. Hydrochlorothiazide-irbesartan and Pioglitazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Thiazides can raise blood glucose and may reduce the effect of pioglitazone. Glycemic control may worsen.
How serious is the interaction between Hydrochlorothiazide-irbesartan and Pioglitazone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c and adjust therapy as needed.
What other medicines interact with Hydrochlorothiazide-irbesartan?
MediHelp also lists interactions of Hydrochlorothiazide-irbesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-irbesartan page.
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