Drug interactions
Hydrochlorothiazide-irbesartan + Quinine
Severity: Minor
Hydrochlorothiazide-irbesartan and Quinine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrochlorothiazide may theoretically reduce quinine renal clearance, but no clinically significant effect is established. Both can contribute to electrolyte disturbance relevant to quinine QT effects.
What this interaction means in plain words
Hydrochlorothiazide-irbesartan and Quinine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Hydrochlorothiazide-irbesartan belongs to Cardiovascular; Quinine belongs to Anti Parasitic.
Why it happens
Theoretical competition for renal tubular secretion; thiazide-induced hypokalemia or hypomagnesemia may enhance QT risk.
What to do
Check potassium and magnesium before and during quinine therapy and correct deficits.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-irbesartan
- Aliskiren + Hydrochlorothiazide-irbesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-irbesartan Contraindicated
- Hydrochlorothiazide-irbesartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-irbesartan Major
- Amifostine + Hydrochlorothiazide-irbesartan Major
- Amiloride + Hydrochlorothiazide-irbesartan Major
Other interactions of Quinine
- Arsenic trioxide + Quinine Contraindicated
- Dofetilide + Quinine Contraindicated
- Dronedarone + Quinine Contraindicated
- Ibutilide + Quinine Contraindicated
- Mefloquine + Quinine Contraindicated
- Nilotinib + Quinine Contraindicated
Frequently asked questions
Can I take Hydrochlorothiazide-irbesartan with Quinine?
MediHelp rates the interaction as minor. Hydrochlorothiazide-irbesartan and Quinine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Hydrochlorothiazide may theoretically reduce quinine renal clearance, but no clinically significant effect is established. Both can contribute to electrolyte disturbance relevant to quinine QT effects.
How serious is the interaction between Hydrochlorothiazide-irbesartan and Quinine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check potassium and magnesium before and during quinine therapy and correct deficits.
What other medicines interact with Hydrochlorothiazide-irbesartan?
MediHelp also lists interactions of Hydrochlorothiazide-irbesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-irbesartan page.
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