Drug interactions
Hydrochlorothiazide-irbesartan + Salmeterol
Severity: Moderate
Hydrochlorothiazide-irbesartan and Salmeterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both salmeterol and hydrochlorothiazide can lower serum potassium, and the effects can be additive, particularly with high doses of the beta-agonist. Hypokalemia may provoke arrhythmias, especially in patients with heart disease or hypoxia.
What this interaction means in plain words
Hydrochlorothiazide-irbesartan and Salmeterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrochlorothiazide-irbesartan belongs to Cardiovascular; Salmeterol belongs to Respiratory.
Why it happens
Beta-2 stimulation shifts potassium into cells while the thiazide increases urinary potassium loss, producing additive hypokalemia.
What to do
Monitor serum potassium in patients with risk factors, such as heart disease or high-dose beta-agonist use. Replace potassium as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Hydrochlorothiazide-irbesartan and Salmeterol, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Hydrochlorothiazide-irbesartan
- Aliskiren + Hydrochlorothiazide-irbesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-irbesartan Contraindicated
- Hydrochlorothiazide-irbesartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-irbesartan Major
- Amifostine + Hydrochlorothiazide-irbesartan Major
- Amiloride + Hydrochlorothiazide-irbesartan Major
Other interactions of Salmeterol
- Ritonavir + Salmeterol Contraindicated
- Salmeterol + Saquinavir Contraindicated
- Amitriptyline + Salmeterol Major
- Arformoterol + Salmeterol Major
- Atazanavir + Salmeterol Major
- Budesonide-formoterol + Salmeterol Major
Frequently asked questions
Can I take Hydrochlorothiazide-irbesartan with Salmeterol?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-irbesartan and Salmeterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both salmeterol and hydrochlorothiazide can lower serum potassium, and the effects can be additive, particularly with high doses of the beta-agonist. Hypokalemia may provoke arrhythmias, especially in patients with heart disease or hypoxia.
How serious is the interaction between Hydrochlorothiazide-irbesartan and Salmeterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium in patients with risk factors, such as heart disease or high-dose beta-agonist use. Replace potassium as needed.
What other medicines interact with Hydrochlorothiazide-irbesartan?
MediHelp also lists interactions of Hydrochlorothiazide-irbesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-irbesartan page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
