Drug interactions
Hydrochlorothiazide-irbesartan + Tadalafil
Severity: Minor
Hydrochlorothiazide-irbesartan and Tadalafil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tadalafil is a vasodilator and can add to the blood pressure lowering of irbesartan and hydrochlorothiazide. Symptomatic hypotension, dizziness or syncope can occur, particularly after starting or raising the dose.
What this interaction means in plain words
Hydrochlorothiazide-irbesartan and Tadalafil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Hydrochlorothiazide-irbesartan belongs to Cardiovascular; Tadalafil belongs to Genitourinary.
Why it happens
Additive vasodilation from PDE5 inhibition with antihypertensive effects of ARB and diuretic.
What to do
Start tadalafil at a low dose and advise patients to rise slowly. Monitor blood pressure, especially in volume-depleted patients.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-irbesartan
- Aliskiren + Hydrochlorothiazide-irbesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-irbesartan Contraindicated
- Hydrochlorothiazide-irbesartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-irbesartan Major
- Amifostine + Hydrochlorothiazide-irbesartan Major
- Amiloride + Hydrochlorothiazide-irbesartan Major
Other interactions of Tadalafil
- Amyl nitrite + Tadalafil Contraindicated
- Isosorbide dinitrate + Tadalafil Contraindicated
- Isosorbide mononitrate + Tadalafil Contraindicated
- Nitroglycerin po + Tadalafil Contraindicated
- Nitroglycerin rectal + Tadalafil Contraindicated
- Nitroglycerin sublingual + Tadalafil Contraindicated
Frequently asked questions
Can I take Hydrochlorothiazide-irbesartan with Tadalafil?
MediHelp rates the interaction as minor. Hydrochlorothiazide-irbesartan and Tadalafil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tadalafil is a vasodilator and can add to the blood pressure lowering of irbesartan and hydrochlorothiazide. Symptomatic hypotension, dizziness or syncope can occur, particularly after starting or raising the dose.
How serious is the interaction between Hydrochlorothiazide-irbesartan and Tadalafil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start tadalafil at a low dose and advise patients to rise slowly. Monitor blood pressure, especially in volume-depleted patients.
What other medicines interact with Hydrochlorothiazide-irbesartan?
MediHelp also lists interactions of Hydrochlorothiazide-irbesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-irbesartan page.
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