Drug interactions
Hydrochlorothiazide-irbesartan + Tretinoin
Severity: Minor
Hydrochlorothiazide-irbesartan and Tretinoin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrochlorothiazide is a known photosensitizer and tretinoin increases skin sensitivity to ultraviolet light, so combined use may increase sunburn or phototoxic reactions. This is mainly a concern with topical tretinoin on exposed skin, and the effect is usually manageable.
What this interaction means in plain words
Hydrochlorothiazide-irbesartan and Tretinoin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Hydrochlorothiazide-irbesartan belongs to Cardiovascular; Tretinoin belongs to Dermatology.
Why it happens
Additive photosensitizing effects of both drugs on the skin.
What to do
Advise strict sun protection with broad-spectrum sunscreen and protective clothing. Reduce sun exposure and review therapy if phototoxic reactions develop.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Hydrochlorothiazide-irbesartan and Tretinoin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Hydrochlorothiazide-irbesartan
- Aliskiren + Hydrochlorothiazide-irbesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-irbesartan Contraindicated
- Hydrochlorothiazide-irbesartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-irbesartan Major
- Amifostine + Hydrochlorothiazide-irbesartan Major
- Amiloride + Hydrochlorothiazide-irbesartan Major
Other interactions of Tretinoin
- Doxycycline + Tretinoin Major
- Minocycline + Tretinoin Major
- Omadacycline + Tretinoin Major
- Palovarotene + Tretinoin Major
- Sarecycline + Tretinoin Major
- Tetracycline + Tretinoin Major
Frequently asked questions
Can I take Hydrochlorothiazide-irbesartan with Tretinoin?
MediHelp rates the interaction as minor. Hydrochlorothiazide-irbesartan and Tretinoin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Hydrochlorothiazide is a known photosensitizer and tretinoin increases skin sensitivity to ultraviolet light, so combined use may increase sunburn or phototoxic reactions. This is mainly a concern with topical tretinoin on exposed skin, and the effect is usually manageable.
How serious is the interaction between Hydrochlorothiazide-irbesartan and Tretinoin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise strict sun protection with broad-spectrum sunscreen and protective clothing. Reduce sun exposure and review therapy if phototoxic reactions develop.
What other medicines interact with Hydrochlorothiazide-irbesartan?
MediHelp also lists interactions of Hydrochlorothiazide-irbesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-irbesartan page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
