Drug interactions
Hydrochlorothiazide-irbesartan + Triamterene
Severity: Major
Hydrochlorothiazide-irbesartan and Triamterene: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Triamterene and irbesartan both promote potassium retention, raising the risk of hyperkalemia, especially with renal impairment. Hydrochlorothiazide offsets this only partly.
What this interaction means in plain words
Hydrochlorothiazide-irbesartan and Triamterene can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Hydrochlorothiazide-irbesartan belongs to Cardiovascular; Triamterene belongs to Cardiovascular.
Why it happens
Triamterene blocks epithelial sodium channels and irbesartan reduces aldosterone effect, both decreasing renal potassium excretion.
What to do
Avoid routine combination where possible; if used, monitor serum potassium and renal function closely. Stop triamterene if hyperkalemia develops.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Hydrochlorothiazide-irbesartan
- Aliskiren + Hydrochlorothiazide-irbesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-irbesartan Contraindicated
- Hydrochlorothiazide-irbesartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-irbesartan Major
- Amifostine + Hydrochlorothiazide-irbesartan Major
- Amiloride + Hydrochlorothiazide-irbesartan Major
Other interactions of Triamterene
- Amiloride + Triamterene Contraindicated
- Eplerenone + Triamterene Contraindicated
- Potassium citrate / citric acid + Triamterene Contraindicated
- Potassium citrate + Triamterene Contraindicated
- Spironolactone + Triamterene Contraindicated
- Aceclofenac + Triamterene Major
Frequently asked questions
Can I take Hydrochlorothiazide-irbesartan with Triamterene?
MediHelp rates the interaction as major. Hydrochlorothiazide-irbesartan and Triamterene can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Triamterene and irbesartan both promote potassium retention, raising the risk of hyperkalemia, especially with renal impairment. Hydrochlorothiazide offsets this only partly.
How serious is the interaction between Hydrochlorothiazide-irbesartan and Triamterene?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid routine combination where possible; if used, monitor serum potassium and renal function closely. Stop triamterene if hyperkalemia develops.
What other medicines interact with Hydrochlorothiazide-irbesartan?
MediHelp also lists interactions of Hydrochlorothiazide-irbesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-irbesartan page.
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