Drug interactions
Hydrochlorothiazide-irbesartan + Valsartan
Severity: Major
Hydrochlorothiazide-irbesartan and Valsartan: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining two angiotensin receptor blockers gives dual renin-angiotensin blockade with no added benefit and a higher risk of hypotension, hyperkalemia and renal impairment. The combination also duplicates the irbesartan component of the product.
What this interaction means in plain words
Hydrochlorothiazide-irbesartan and Valsartan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Hydrochlorothiazide-irbesartan belongs to Cardiovascular; Valsartan belongs to Cardiovascular.
Why it happens
Duplicate AT1 receptor blockade produces additive reduction in aldosterone-mediated potassium excretion and in glomerular filtration pressure.
What to do
Avoid using two ARBs together and keep a single agent from this class. If the combination was used, monitor potassium, creatinine and blood pressure closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Hydrochlorothiazide-irbesartan
- Aliskiren + Hydrochlorothiazide-irbesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-irbesartan Contraindicated
- Hydrochlorothiazide-irbesartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-irbesartan Major
- Amifostine + Hydrochlorothiazide-irbesartan Major
- Amiloride + Hydrochlorothiazide-irbesartan Major
Other interactions of Valsartan
- Aliskiren + Valsartan Contraindicated
- Sparsentan + Valsartan Contraindicated
- Aldesleukin + Valsartan Major
- Amifostine + Valsartan Major
- Amiloride + Valsartan Major
- Amlodipine-benazepril + Valsartan Major
Frequently asked questions
Can I take Hydrochlorothiazide-irbesartan with Valsartan?
MediHelp rates the interaction as major. Hydrochlorothiazide-irbesartan and Valsartan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combining two angiotensin receptor blockers gives dual renin-angiotensin blockade with no added benefit and a higher risk of hypotension, hyperkalemia and renal impairment. The combination also duplicates the irbesartan component of the product.
How serious is the interaction between Hydrochlorothiazide-irbesartan and Valsartan?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid using two ARBs together and keep a single agent from this class. If the combination was used, monitor potassium, creatinine and blood pressure closely.
What other medicines interact with Hydrochlorothiazide-irbesartan?
MediHelp also lists interactions of Hydrochlorothiazide-irbesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-irbesartan page.
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