Drug interactions
Hydrochlorothiazide-lisinopril + Irbesartan
Severity: Major
Hydrochlorothiazide-lisinopril and Irbesartan: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Adding irbesartan to an ACE inhibitor gives dual renin-angiotensin blockade, which raises the risk of hypotension, hyperkalemia and renal impairment without proven added benefit. The thiazide does not reliably prevent these effects.
What this interaction means in plain words
Hydrochlorothiazide-lisinopril and Irbesartan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Hydrochlorothiazide-lisinopril belongs to Cardiovascular; Irbesartan belongs to Cardiovascular.
Why it happens
Dual blockade of the renin-angiotensin-aldosterone system reduces aldosterone and glomerular filtration pressure.
What to do
Avoid combining an ARB with an ACE inhibitor. If it is unavoidable, monitor potassium, creatinine and blood pressure closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Hydrochlorothiazide-lisinopril
- Dofetilide + Hydrochlorothiazide-lisinopril Contraindicated
- Hydrochlorothiazide-lisinopril + Sacubitril / valsartan Contraindicated
- Amifostine + Hydrochlorothiazide-lisinopril Major
- Amiloride + Hydrochlorothiazide-lisinopril Major
- Benazepril + Hydrochlorothiazide-lisinopril Major
- Bendroflumethiazide + Hydrochlorothiazide-lisinopril Major
Other interactions of Irbesartan
- Aliskiren + Irbesartan Contraindicated
- Irbesartan + Sparsentan Contraindicated
- Amifostine + Irbesartan Major
- Amiloride + Irbesartan Major
- Amlodipine-benazepril + Irbesartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Irbesartan Major
Frequently asked questions
Can I take Hydrochlorothiazide-lisinopril with Irbesartan?
MediHelp rates the interaction as major. Hydrochlorothiazide-lisinopril and Irbesartan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Adding irbesartan to an ACE inhibitor gives dual renin-angiotensin blockade, which raises the risk of hypotension, hyperkalemia and renal impairment without proven added benefit. The thiazide does not reliably prevent these effects.
How serious is the interaction between Hydrochlorothiazide-lisinopril and Irbesartan?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining an ARB with an ACE inhibitor. If it is unavoidable, monitor potassium, creatinine and blood pressure closely.
What other medicines interact with Hydrochlorothiazide-lisinopril?
MediHelp also lists interactions of Hydrochlorothiazide-lisinopril with, for example, Dofetilide, Sacubitril / valsartan, Amifostine. The full list is on the Hydrochlorothiazide-lisinopril page.
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