Drug interactions
Hydrochlorothiazide-lisinopril + Isoproterenol
Severity: Moderate
Hydrochlorothiazide-lisinopril and Isoproterenol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isoproterenol can lower serum potassium through beta-adrenergic stimulation, adding to thiazide-induced potassium loss. This raises the risk of arrhythmias in susceptible patients.
What this interaction means in plain words
Hydrochlorothiazide-lisinopril and Isoproterenol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrochlorothiazide-lisinopril belongs to Cardiovascular; Isoproterenol belongs to Respiratory.
Why it happens
Beta-agonist induced cellular potassium uptake adds to renal potassium wasting from the thiazide.
What to do
Monitor serum potassium and ECG during isoproterenol therapy and correct hypokalemia promptly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-lisinopril
- Dofetilide + Hydrochlorothiazide-lisinopril Contraindicated
- Hydrochlorothiazide-lisinopril + Sacubitril / valsartan Contraindicated
- Amifostine + Hydrochlorothiazide-lisinopril Major
- Amiloride + Hydrochlorothiazide-lisinopril Major
- Benazepril + Hydrochlorothiazide-lisinopril Major
- Bendroflumethiazide + Hydrochlorothiazide-lisinopril Major
Other interactions of Isoproterenol
Frequently asked questions
Can I take Hydrochlorothiazide-lisinopril with Isoproterenol?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-lisinopril and Isoproterenol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Isoproterenol can lower serum potassium through beta-adrenergic stimulation, adding to thiazide-induced potassium loss. This raises the risk of arrhythmias in susceptible patients.
How serious is the interaction between Hydrochlorothiazide-lisinopril and Isoproterenol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and ECG during isoproterenol therapy and correct hypokalemia promptly.
What other medicines interact with Hydrochlorothiazide-lisinopril?
MediHelp also lists interactions of Hydrochlorothiazide-lisinopril with, for example, Dofetilide, Sacubitril / valsartan, Amifostine. The full list is on the Hydrochlorothiazide-lisinopril page.
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