Drug interactions
Hydrochlorothiazide-lisinopril + Methoxsalen
Severity: Moderate
Hydrochlorothiazide-lisinopril and Methoxsalen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrochlorothiazide is a recognized photosensitizer, and methoxsalen is used to induce photosensitivity for PUVA therapy. Together they may enhance phototoxic reactions such as severe sunburn or blistering.
What this interaction means in plain words
Hydrochlorothiazide-lisinopril and Methoxsalen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrochlorothiazide-lisinopril belongs to Cardiovascular; Methoxsalen belongs to Anti Fungals.
Why it happens
Additive photosensitizing effects of the two agents on skin exposed to ultraviolet light.
What to do
Review the UVA dose with the treating dermatologist and advise strict photoprotection and avoidance of extra sun exposure. Consider whether the thiazide can be substituted during PUVA treatment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-lisinopril
- Dofetilide + Hydrochlorothiazide-lisinopril Contraindicated
- Hydrochlorothiazide-lisinopril + Sacubitril / valsartan Contraindicated
- Amifostine + Hydrochlorothiazide-lisinopril Major
- Amiloride + Hydrochlorothiazide-lisinopril Major
- Benazepril + Hydrochlorothiazide-lisinopril Major
- Bendroflumethiazide + Hydrochlorothiazide-lisinopril Major
Other interactions of Methoxsalen
- Fezolinetant + Methoxsalen Contraindicated
- Demeclocycline + Methoxsalen Major
- Fedratinib + Methoxsalen Major
- Methoxsalen + Pirfenidone Major
- Methoxsalen + Tasimelteon Major
- Adapalene + Methoxsalen Moderate
Frequently asked questions
Can I take Hydrochlorothiazide-lisinopril with Methoxsalen?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-lisinopril and Methoxsalen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Hydrochlorothiazide is a recognized photosensitizer, and methoxsalen is used to induce photosensitivity for PUVA therapy. Together they may enhance phototoxic reactions such as severe sunburn or blistering.
How serious is the interaction between Hydrochlorothiazide-lisinopril and Methoxsalen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Review the UVA dose with the treating dermatologist and advise strict photoprotection and avoidance of extra sun exposure. Consider whether the thiazide can be substituted during PUVA treatment.
What other medicines interact with Hydrochlorothiazide-lisinopril?
MediHelp also lists interactions of Hydrochlorothiazide-lisinopril with, for example, Dofetilide, Sacubitril / valsartan, Amifostine. The full list is on the Hydrochlorothiazide-lisinopril page.
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