Drug interactions
Hydrochlorothiazide-lisinopril + Nadolol
Severity: Minor
Hydrochlorothiazide-lisinopril and Nadolol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nadolol adds to the blood pressure lowering of the ACE inhibitor and thiazide, which may be intended but can cause hypotension or bradycardia. Thiazides can also modestly raise glucose and lipids, and nadolol may mask hypoglycemia symptoms in diabetic patients.
What this interaction means in plain words
Hydrochlorothiazide-lisinopril and Nadolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Hydrochlorothiazide-lisinopril belongs to Cardiovascular; Nadolol belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic antihypertensive effects through different mechanisms.
What to do
Monitor blood pressure and heart rate when starting or titrating. Adjust doses if symptomatic hypotension occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-lisinopril
- Dofetilide + Hydrochlorothiazide-lisinopril Contraindicated
- Hydrochlorothiazide-lisinopril + Sacubitril / valsartan Contraindicated
- Amifostine + Hydrochlorothiazide-lisinopril Major
- Amiloride + Hydrochlorothiazide-lisinopril Major
- Benazepril + Hydrochlorothiazide-lisinopril Major
- Bendroflumethiazide + Hydrochlorothiazide-lisinopril Major
Other interactions of Nadolol
- Acebutolol + Nadolol Major
- Adrenaline-articaine + Nadolol Major
- Albuterol + Nadolol Major
- Amifostine + Nadolol Major
- Amiodarone + Nadolol Major
- Arformoterol + Nadolol Major
Frequently asked questions
Can I take Hydrochlorothiazide-lisinopril with Nadolol?
MediHelp rates the interaction as minor. Hydrochlorothiazide-lisinopril and Nadolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nadolol adds to the blood pressure lowering of the ACE inhibitor and thiazide, which may be intended but can cause hypotension or bradycardia. Thiazides can also modestly raise glucose and lipids, and nadolol may mask hypoglycemia symptoms in diabetic patients.
How serious is the interaction between Hydrochlorothiazide-lisinopril and Nadolol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate when starting or titrating. Adjust doses if symptomatic hypotension occurs.
What other medicines interact with Hydrochlorothiazide-lisinopril?
MediHelp also lists interactions of Hydrochlorothiazide-lisinopril with, for example, Dofetilide, Sacubitril / valsartan, Amifostine. The full list is on the Hydrochlorothiazide-lisinopril page.
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