Drug interactions
Hydrochlorothiazide-lisinopril + Oliceridine
Severity: Moderate
Hydrochlorothiazide-lisinopril and Oliceridine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Opioids can cause hypotension, particularly in volume-depleted patients on diuretics and ACE inhibitors. Opioids may also promote antidiuretic hormone release, which could reduce diuretic effect. The two effects can complicate fluid and blood pressure management.
What this interaction means in plain words
Hydrochlorothiazide-lisinopril and Oliceridine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrochlorothiazide-lisinopril belongs to Cardiovascular; Oliceridine belongs to Musculoskeletal.
Why it happens
Additive hypotensive effects of opioid-induced vasodilation with diuretic volume depletion, and opioid-related antidiuretic hormone release opposing diuresis.
What to do
Monitor blood pressure, fluid status and urine output after oliceridine administration, and adjust the diuretic dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-lisinopril
- Dofetilide + Hydrochlorothiazide-lisinopril Contraindicated
- Hydrochlorothiazide-lisinopril + Sacubitril / valsartan Contraindicated
- Amifostine + Hydrochlorothiazide-lisinopril Major
- Amiloride + Hydrochlorothiazide-lisinopril Major
- Benazepril + Hydrochlorothiazide-lisinopril Major
- Bendroflumethiazide + Hydrochlorothiazide-lisinopril Major
Other interactions of Oliceridine
- Isocarboxazid + Oliceridine Contraindicated
- Alprazolam + Oliceridine Major
- Amiodarone + Oliceridine Major
- Amisulpride + Oliceridine Major
- Amitriptyline + Oliceridine Major
- Amobarbital + Oliceridine Major
Frequently asked questions
Can I take Hydrochlorothiazide-lisinopril with Oliceridine?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-lisinopril and Oliceridine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Opioids can cause hypotension, particularly in volume-depleted patients on diuretics and ACE inhibitors. Opioids may also promote antidiuretic hormone release, which could reduce diuretic effect. The two effects can complicate fluid and blood pressure management.
How serious is the interaction between Hydrochlorothiazide-lisinopril and Oliceridine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, fluid status and urine output after oliceridine administration, and adjust the diuretic dose if needed.
What other medicines interact with Hydrochlorothiazide-lisinopril?
MediHelp also lists interactions of Hydrochlorothiazide-lisinopril with, for example, Dofetilide, Sacubitril / valsartan, Amifostine. The full list is on the Hydrochlorothiazide-lisinopril page.
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