Drug interactions
Hydrochlorothiazide-lisinopril + Pivmecillinam
Severity: Minor
Hydrochlorothiazide-lisinopril and Pivmecillinam: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazides and penicillins such as mecillinam compete for renal tubular secretion, which may modestly slow elimination of the penicillin. The clinical impact is usually small given the wide safety margin of the penicillin.
What this interaction means in plain words
Hydrochlorothiazide-lisinopril and Pivmecillinam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Hydrochlorothiazide-lisinopril belongs to Cardiovascular; Pivmecillinam belongs to Anti Bacterial.
Why it happens
Competition for renal tubular secretion via organic anion transporters.
What to do
No dose change is usually needed. Be alert to adverse effects in patients with impaired renal function.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-lisinopril
- Dofetilide + Hydrochlorothiazide-lisinopril Contraindicated
- Hydrochlorothiazide-lisinopril + Sacubitril / valsartan Contraindicated
- Amifostine + Hydrochlorothiazide-lisinopril Major
- Amiloride + Hydrochlorothiazide-lisinopril Major
- Benazepril + Hydrochlorothiazide-lisinopril Major
- Bendroflumethiazide + Hydrochlorothiazide-lisinopril Major
Other interactions of Pivmecillinam
- Doxycycline + Pivmecillinam Moderate
- Minocycline + Pivmecillinam Moderate
- Pivmecillinam + Probenecid Moderate
- Pivmecillinam + Tetracycline Moderate
- Acetylsalicylic acid + Pivmecillinam Minor
- Acyclovir + Pivmecillinam Minor
Frequently asked questions
Can I take Hydrochlorothiazide-lisinopril with Pivmecillinam?
MediHelp rates the interaction as minor. Hydrochlorothiazide-lisinopril and Pivmecillinam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Thiazides and penicillins such as mecillinam compete for renal tubular secretion, which may modestly slow elimination of the penicillin. The clinical impact is usually small given the wide safety margin of the penicillin.
How serious is the interaction between Hydrochlorothiazide-lisinopril and Pivmecillinam?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed. Be alert to adverse effects in patients with impaired renal function.
What other medicines interact with Hydrochlorothiazide-lisinopril?
MediHelp also lists interactions of Hydrochlorothiazide-lisinopril with, for example, Dofetilide, Sacubitril / valsartan, Amifostine. The full list is on the Hydrochlorothiazide-lisinopril page.
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